Systems and methods for correlating wireless communication performance with vehicle system configurations determine wireless message characteristics of wireless messages communicated with vehicles in vehicle systems and locations along a route where the wireless message characteristics were determined. The wireless message characteristics and the locations can be determined during movement of the vehicle systems along a route. Consist configuration information about the one or more vehicle systems is obtained, and a signal propagation profile is determined based on the wireless message characteristics, the locations where the wireless message characteristics were determined, and the consist configuration information. The signal propagation profile can represent one or more relationships between the wireless message characteristics, the consist configuration information, and the locations along the route. This profile can be used to control movement and/or communication of other vehicle systems, to generate trip plans for other vehicle systems, to diagnose communication faults, and the like.