Invention Grant
- Patent Title: Combinations of mRNAs encoding immune modulating polypeptides and uses thereof
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Application No.: US16219418Application Date: 2018-12-13
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Publication No.: US10322091B2Publication Date: 2019-06-18
- Inventor: Joshua Frederick , Ailin Bai , Vladimir Presnyak , Stephen Hoge , Kerry Benenato , Iain McFadyen , Ellalahewage Sathyajith Kumarasinghe , Susannah Hewitt
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Amy E. Mandragouras, Esq.; Ariana D. Harris
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K9/51 ; A61K38/17 ; A61K38/20 ; A61K9/00 ; A61K39/39 ; A61K45/06 ; A61K9/127 ; C07K14/54 ; C07K14/545 ; C07K14/705 ; A61P35/00 ; A61K39/395 ; A61K39/00 ; B82Y5/00 ; C12N15/88
Abstract:
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
Public/Granted literature
- US20190105280A1 COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF Public/Granted day:2019-04-11
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