Systems and methods for modification of autonomous vehicle operation in association with emergency events are disclosed. According to aspects, a computing device may detect the occurrence of an emergency event and may determine a current operation of an autonomous vehicle as well as a planned operation of an emergency vehicle. The computing device may determine a modification to the operation of the autonomous vehicle, where the modification may direct the autonomous vehicle to operate in a way that enables the emergency vehicle to more effectively or efficiently address or handle the emergency event. The computing device may generate a set of instructions for the autonomous vehicle to execute to cause the autonomous vehicle to undertake the operation modification.