A hand-held vacuum cleaner includes a dust cup including a first cyclone, a cyclone assembly, and a filtration member. The cyclone assembly includes a plurality of second cyclones, a guiding channel is defined between two of the plurality of the second cyclones, the guiding channel is in communication with the first air vent and an airflow is guided to an outer circumference of the cyclone assembly by the guiding channel along a tangent line to a circumferential wall of the second cyclone adjacent to the guiding channel, each second cyclone has an air inducing notch and is provided with an air guiding pipe, the filtration member is disposed along the outer circumference of the cyclone assembly, and the airflow in the outer circumference of the cyclone assembly tangentially enters the second cyclone through the filtration member and the air inducing notch.