Invention Grant
- Patent Title: Cyclic compounds useful as modulators of TNF α
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Application No.: US15749611Application Date: 2016-08-02
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Publication No.: US10335392B2Publication Date: 2019-07-02
- Inventor: Hai-Yun Xiao , T.G. Murali Dhar , Bin Jiang , Jingwu Duan
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- International Application: PCT/US2016/045104 WO 20160802
- International Announcement: WO2017/023902 WO 20170209
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D487/14 ; A61K31/4184 ; A61K31/4188 ; A61P37/02

Abstract:
Disclosed are compounds of Formula (I) or a salt thereof, wherein: Ring A is 3- to 6-membered carbocyclic or heterocyclic ring; X is CR1 or N; Y is —(CR5R5)m—; Z is —(CR5R5)n—; and q, R1, R2, R3, R4, R6, R7, R8, R9, and R10 are defined herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Public/Granted literature
- US20180221344A1 CYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ALPHA Public/Granted day:2018-08-09
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