- 专利标题: Aryl acylsulfonamides as BLT1 antagonists
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申请号: US15767371申请日: 2016-11-28
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公开(公告)号: US10336733B2公开(公告)日: 2019-07-02
- 发明人: Yongxin Han , Jongwon Lim , Satyanarayana Tummanapalli , Phieng Siliphaivanh , Kerrie Spencer
- 申请人: Merck Sharp & Dohme Corp. , Yongxin Han , Jongwon Lim , Satyanarayana Tummanapalli , Phieng Siliphaivanh , Kerrie Spencer
- 申请人地址: US NJ Rahway
- 专利权人: Merk Sharp & Dohme Corp.
- 当前专利权人: Merk Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Baerbel R. Brown; Catherine D. Fitch
- 国际申请: PCT/US2016/063806 WO 20161128
- 国际公布: WO2017/095722 WO 20170608
- 主分类号: C07D417/06
- IPC分类号: C07D417/06 ; C07D413/06 ; C07D311/22 ; C07D405/06 ; A61K31/353 ; A61K9/20
摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B4 receptor 1 (BLT1) and may be useful in the treatment, prevention and suppression of diseases mediated by the leukotriene B4 receptor 1 (BLT1). The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, insulin resistance, hyperglycemia, dyslipidemia, lipid disorders, obesity, hypertension, Non-alcoholic fatty liver disease/nonalcoholic steatoepatitis, metabolic syndrome, atherosclerosis, and cancer.
公开/授权文献
- US20180305342A1 ARYL ACYLSULFONAMIDES AS BLT1 ANTAGONISTS 公开/授权日:2018-10-25
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