Invention Grant
- Patent Title: N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2
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Application No.: US15899821Application Date: 2018-02-20
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Publication No.: US10336774B2Publication Date: 2019-07-02
- Inventor: Christine Hiu-Tung Chen , Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , John William Giraldes , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Martin Sendzik , Troy Douglas Smith , Bakary-Barry Toure , Sarah Williams
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D401/14 ; C07D471/10 ; C07D498/10 ; C07D241/18 ; C07D241/20 ; C07D403/04 ; C07D491/107 ; C07D495/10
Abstract:
The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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