Invention Grant
- Patent Title: Pharmaceutical composition for treatment of cancer comprising RNA oligonucleotide
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Application No.: US15327596Application Date: 2016-10-14
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Publication No.: US10337016B2Publication Date: 2019-07-02
- Inventor: Byong-Seok Choi , Suk-Jo Kang , Janghyun Lee , Ji Youn Min , Dongmin Chun , Si-Eun Sung
- Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Daejeon
- Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Daejeon
- Agency: Harness, Dickey & Pierce, P.L.C.
- Priority: KR10-2015-0144306 20151015; KR10-2016-0085582 20160706
- International Application: PCT/KR2016/011571 WO 20161014
- International Announcement: WO2017/065563 WO 20170420
- Main IPC: C12N15/117
- IPC: C12N15/117 ; A61K31/713 ; C12N15/113
Abstract:
The present disclosure provides a pharmaceutical composition for treating cancer comprising an RNA oligonucleotide having a particular sequence and structure. Specifically, when a cell line is treated with an RNA oligonucleotide having specific sequence and helical bend structure according to the present disclosure, the expression of ISG56 is increased and apoptosis of cancer cells is induced. Thus, a composition comprising the RNA oligonucleotide can be used as an anticancer agent.
Public/Granted literature
- US20170306330A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER COMPRISING RNA OLIGONUCLEOTIDE Public/Granted day:2017-10-26
Information query
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