- 专利标题： Process for the preparation of chiral 2-aryl morpholines
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申请号： US15175779申请日： 2016-06-07
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公开(公告)号： US10337039B2公开(公告)日： 2019-07-02
- 发明人: Rene Trussardi , Hans Iding
- 申请人： Hoffmann-La Roche Inc.
- 申请人地址： US NJ Little Falls
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Little Falls
- 代理商 Brian L. Buckwalter
- 优先权： EP13196638 20131211
- 主分类号： C12P7/02
- IPC分类号： C12P7/02 ; C12P7/22 ; C12P13/00 ; C12P17/14 ; C07D265/30
摘要：
The invention relates to a novel process for the preparation of chiral 2-(4-aminophenyl) morpholines of the formula wherein R1 is hydrogen an amino protecting group. The chiral 2-(4-aminophenyl) morpholines of the formula I are key intermediates for the preparation of compounds that have a good affinity to the trace amine associated receptors (TAARs).
公开/授权文献
- US20160289718A1 PROCESS FOR THE PREPARATION OF CHIRAL 2-ARYL MORPHOLINES 公开/授权日：2016-10-06
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