A method and device for processing an input/output (I/O) request in a network file system (NFS) includes sending, by a NFS server, a request for parsing the unidentifiable NFS FH to a centralized controller when a NFS file handle (NFS FH) in an I/O request cannot be identified, receiving, by the NFS server, a file identifier that corresponds to the unidentifiable NFS FH from the centralized controller according to the parsing request, where the file identifier is determined according to a pre-stored correspondence between NFS FHs and file identifiers, and processing, by the NFS server, the I/O request according to the file identifier.