An open roof construction comprises at least one guide rail and front and rear closure panels. An operating mechanism supports the front panel and is adjustable between a closed position and an open position. The operating mechanism comprises rear supports connected to the front panel and two parallel guide tracks. A rear guide track portion extends rearwardly beyond the roof opening. The rear panel and the sidewardly adjacent fixed roof include a passage opening to allow the supports to support the front panel when the support is positioned in the rear guide track portion. The rear panel and the adjacent fixed roof are each provided with a seal to close the passage opening and to allow the support member to move between the seals, which, when viewed from above, extend in a non-parallel fashion with respect to each other and to the guide track.