Systems and methods for disabling autonomous vehicle input devices are provided. In one example embodiment, a computer implemented method includes identifying an operating mode of an autonomous vehicle. The method includes determining one or more vehicle input devices to be disabled based at least in part on the operating mode of the autonomous vehicle. The vehicle input devices are located onboard the autonomous vehicle. The method includes disabling the one or more vehicle input devices based at least in part on the identified operating mode of the autonomous vehicle such that an input by a user with respect to the one or more vehicle input devices does not affect an operation of the autonomous vehicle.