Invention Grant
- Patent Title: Production method for 2-fluoro-4-borono-L-phenylalanine, and precursor of 2-fluoro-4-borono-L-phenylalanine
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Application No.: US15625909Application Date: 2017-06-16
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Publication No.: US10344042B2Publication Date: 2019-07-09
- Inventor: Hiroshi Takenaka , Yoichiro Ohta , Yusuke Taguchi , Sayuri Ueda , Yuko Ishino , Tomohiro Yoshikawa , Hideki Nakashima , Kohki Uehara , Mitsunori Kirihata
- Applicant: Stella Pharma Corporation , Osaka Prefecture University Public Corporation
- Applicant Address: JP Osaka JP Osaka
- Assignee: Stella Pharma Corporation,Osaka Prefecture University Public Corporation
- Current Assignee: Stella Pharma Corporation,Osaka Prefecture University Public Corporation
- Current Assignee Address: JP Osaka JP Osaka
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: JP2013-260451 20131217
- Main IPC: C07F5/02
- IPC: C07F5/02 ; C07C271/22 ; C07C229/36 ; C07C251/24
Abstract:
The present invention involves preparing compounds represented by the following formula: from a compound of the following formula: In these formulae: R1 represents a Br group, an iodine group, a Cl group, an NO2 group, or an NH2 group; R2 represents a halogen group, an NO2 group, an NH2 group, Sn(R6)3, N═N—NR7R8, OSO2R9, N R10R11, phenyliodonium, a heterocyclic group iodine, boric acid, or a borate ester; R30 represents a protective group PG1; R40 or R50 represent hydrogen, a protective group PG2, or C6H5(C6H5)C═N, in which NR40R50 are together.
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