The example of implementation of the invention provides a method used for exploiting a natural gas hydrate reservoir and belongs to the field of natural gas hydrate reservoir exploitation. The method mainly comprises a heat-injecting vertical well and a production horizontal well. The production horizontal well is opened in a segmental manner. In combination with natural gas hydrate heat exploitation, heat flow injected into the vertical well is enabled to heat different positions of the natural gas hydrate reservoir to increase a recovery ratio of the natural gas hydrate reservoir. The method specifically comprises the steps of injecting a heat flow into the natural gas hydrate reservoir by utilizing the vertical well to promote decomposition of the hydrate; firstly opening a horizontal branch of the horizontal well fully and keeping depressurization exploitation. When gas production amount is reduced to a certain degree, dividing a segmentation number based on permeability of the natural gas hydrate reservoir and performing segmental exploitation on the horizontal branch from a toe end to a heel end to realize heat exploitation of the heterogeneous natural gas hydrate reservoir. The method makes full use of a horizontal well structure, reduces exploitation cost and provides effective measures for efficient exploitation of the heterogeneous natural gas hydrate reservoirs.