Invention Grant
- Patent Title: Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain
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Application No.: US14442609Application Date: 2013-11-13
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Publication No.: US10351575B2Publication Date: 2019-07-16
- Inventor: Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
- Applicant: Array BioPharma Inc.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agency: Viksnins Harris Padys Malen LLP
- Agent Sarah S. Mastous
- International Application: PCT/US2013/069951 WO 20131113
- International Announcement: WO2014/078454 WO 20140522
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D491/048 ; C07D405/14 ; C07D231/40 ; C07D231/54 ; C07D401/12 ; C07D403/02 ; C07D403/04 ; C07D403/14 ; C07D405/12 ; C07D413/12 ; C07D453/02 ; C07D231/52 ; C07D231/56 ; C07D401/04 ; C07D409/14 ; C07D471/08

Abstract:
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Public/Granted literature
- US20160355521A1 BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN Public/Granted day:2016-12-08
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