A method and system for simulating patient-specific atrial electrophysiology is disclosed. A patient-specific anatomical atria model is generated from medical image data of a patient. A patient-specific atria electrophysiology model is generated based on the patient-specific anatomical atria model and electrophysiology measurements of the patient. One or more virtual electrophysiological therapies are performed by performing atrial electrophysiology simulations using the patient-specific atria electrophysiology model. Atrial electrophysiology simulation results resulting from the one or more virtual electrophysiological therapies are displayed.