- Patent Title: Methods of treating cardiovascular disease with an ASGR inhibitor
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Application No.: US15279162Application Date: 2016-09-28
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Publication No.: US10358497B2Publication Date: 2019-07-23
- Inventor: Paul Nioi , Jun Zhang , Yang Li
- Applicant: Amgen Inc
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Knobbe, Martens, Olson & Bear, LLP.
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H21/02 ; A61P9/04 ; A61P9/10 ; C07K16/28 ; A61K39/395 ; A61K45/06 ; C07K14/705 ; A61K39/00
Abstract:
Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.
Public/Granted literature
- US20170088620A1 ASGR INHIBITORS Public/Granted day:2017-03-30
Information query
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