Invention Grant
- Patent Title: Therapy regimen and methods to sensitize cancer cells treated with epigenetic therapy to PARP inhibitors in multiple cancers
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Application No.: US15112768Application Date: 2015-01-21
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Publication No.: US10363264B2Publication Date: 2019-07-30
- Inventor: Feyruz Rassool , Stephen Baylin , Carine Robert
- Applicant: THE JOHNS HOPKINS UNIVERSITY , University of Maryland, Baltimore
- Applicant Address: US MD Baltimore US MD Baltimore
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore US MD Baltimore
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- International Application: PCT/US2015/012244 WO 20150121
- International Announcement: WO2015/112598 WO 20150730
- Main IPC: A61K31/706
- IPC: A61K31/706 ; A61K31/4184 ; A61K31/7068 ; A61K31/145 ; A61K31/166 ; A61K31/496 ; A61K31/502 ; A61K31/55 ; A61K31/5025
Abstract:
The presently disclosed subject matter provides methods to treat cancer cells using low doses of DNA demethylating agents and poly ADP ribose polymerase (PARP) inhibitors. Methods also are provided for sensitizing a cell to a PARP inhibitor.
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