- 专利标题: Thermostable respiratory synctial virus (RSV) vaccine compositions
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申请号: US15029064申请日: 2014-10-13
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公开(公告)号: US10369213B2公开(公告)日: 2019-08-06
- 发明人: Akhilesh Bhambhani , Robert K. Evans , Lynne A. Isopi
- 申请人: Merck Sharp & Dohme Corp.
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Andrew W. Custer; Laura M. Ginkel
- 国际申请: PCT/US2014/060233 WO 20141013
- 国际公布: WO2015/057548 WO 20150423
- 主分类号: A61K39/155
- IPC分类号: A61K39/155 ; A61K39/12 ; A61K9/19 ; A61K47/26 ; C12N7/00 ; A61K39/00
摘要:
Methods for improving the drying yield and stability of RSV vaccines comprising a highly thermolabile enveloped live virus and/or one or more RSV protein subunits, are described. Methods for rapid drying of RSV formulations containing between 17.5% and 60% w/w of a non-polymeric sugar and using either conduction or radiation dominant drying mechanisms, are disclosed. The disclosed methods provide for; 1) a dried RSV formulation with improved stability profile; 2) faster drying; and 3) integration of dried RSV into a primary device (such as dual chamber cartridges, foil-pouch devices etc.), pre- as well as post-drying.
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