A quick release support system for a holder of a portable device includes a channel coupled to the holder, a clasp rotatably coupled to the channel and optionally biased to a closed position, and a mounting assembly configured to slide along the channel and be aligned with the clasp in an open position and engage with the clasp in a closed position. The channel can include a variable width opening to progressively align the mounting assembly as the mounting assembly slides along the channel and overarching wings over sides of the channel. Upon engagement with the clasp, the mounting assembly is constrained in all three orthogonal directions. The clasp can be pulled outward from the channel to release the mounting assembly, and the holder with the clasp can be disengaged from the mounting assembly and moved to another location, leaving the mounting assembly in a position for subsequent engagement.