A heating, ventilation, or air conditioning (HVAC) system for a building includes HVAC equipment, a controller, and a predictive modeling system. The HVAC equipment are operable to affect an environmental condition in the building. The controller is configured to determine an operating point for the HVAC equipment and to operate the HVAC equipment at the operating point. The predictive modeling system includes a plurality of HVAC component models and one or more prediction combiners. The HVAC component models are configured to generate a plurality of component model predictions based on the operating point. The prediction combiners are configured to combine the plurality of component model predictions to form a combined model prediction. The controller is configured to use the combined model prediction to optimize the operating point and to operate the HVAC equipment at the optimized operating point.