Embodiments of the disclosure provide a display substrate and a driving method thereof, as well as a display device. The display substrate comprises a plurality of select switch arrays and a plurality of selecting control circuits formed on the base substrate. Each select switch array comprises a plurality of select switches, a first terminal of each select switch being connected to a corresponding data line, a second end of each select switch being connected to a same data voltage input terminal, a control terminal of each select switch being connected to a same selecting control circuit. Each data line is connected with two columns of pixels, and the gate lines connected with the two columns of pixels are different. Each selecting control circuit is connected to a plurality of selecting control signal input terminals and a corresponding select switch array.