A magnetic resonance (MR) imaging system may include at least one controller which may acquire echo information of a region of interest (ROI). The echo information may include first image information suitable for reconstructing at least part of a first image at a selected contrast. The MR imaging system can obtain previously-reconstructed image information of one or more previously-reconstructed images having a contrast different than the selected contrast; extract information from the previously-reconstructed image information; determine spatially adaptive regularization weights for regularized reconstruction based upon the extracted information; and/or reconstruct the first image in formation in accordance with the spatially adaptive regularization weights and the echo information.