Systems and methods for reducing effects of time-division multiplexing noise in mobile communications devices. When cellular communication with time-division multiplexing is detected, such as Global System for Mobiles (GSM) communication with Time Division Multiple Access (TDMA) protocol, total energy and energy at a repetition frequency of the time division multiplexing is measured in audio signals received from several microphones located in the device. A control signal indicating microphones affected by TDMA noise is provided to signal processing subsystems that receive audio signals from the microphones. A beam former circuit may combine two or more audio signals to produce beam formed signals. The control signal may further indicate beam formed signals affected by TDMA noise based on a ratio of the energy from the repetition frequency to the total energy in the beam formed signals.