The disclosure relates to integrated circuit (IC) structures with a single diffusion break (SDB) and end isolation regions, and methods of forming the same after forming a metal gate. A structure may include: a plurality of fins positioned on a substrate; a plurality of metal gates each positioned on the plurality of fins and extending transversely across the plurality of fins; an insulator region positioned on and extending transversely across the plurality of fins between a pair of the plurality of metal gates; at least one single diffusion break (SDB) positioned within the insulator region and one of the plurality of fins; an end isolation region positioned laterally adjacent to a lateral end of one of the plurality of metal gates; and an insulator cap positioned on an upper surface of at least a portion of one of the plurality of metal gates.