A system for interference mitigation including a transmit coupler that samples the RF transmit signal to create a sampled RF transmit signal; a transmit analog canceller that transforms the RF transmit signal to an RF interference cancellation signal, according to a first configuration state; a first receive coupler that combines the RF interference cancellation signal and the RF receive signal to generate a composite RF receive signal; a sampling analog interference filtering system that, in order to remove interference in the transmit band, filters the sampled RF transmit signal to generate a cleaned transmit signal; a first frequency downconverter that converts the transmit signal to a BB transmit signal; a second frequency downconverter that converts the composite RF receive signal to a composite BB receive signal; and an analog-to-digital converter that converts the transmit signal to a digital transmit signal.