An imaging system includes multiple diffractive optical gratings disposed over a two-dimensional array of photosensitive pixels. The different gratings present different patterns and features that are tailored to produce point-spread responses that emphasize different properties of an imaged scene. The different responses are captured by the pixels, and data captured from the responses can be used separately or together to analyze aspects of the scene. The imaging systems can include circuitry to analyze the image data, and to support modes that select between point-spread responses, selections of the pixels, and algorithms for analyzing image data.