Invention Grant
- Patent Title: Benzoimidazole derivatives as PAD4 inhibitors
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Application No.: US15575583Application Date: 2016-05-19
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Publication No.: US10407407B2Publication Date: 2019-09-10
- Inventor: Dominique Amans , Stephen John Atkinson , Michael David Barker , Matthew Campbell , Hawa Diallo , Clement Douault , Neil Stuart Garton , John Liddle , Jessica Fanny Renaux , Robert John Sheppard , Ann Louise Walker , Christopher Roland Wellaway , David Matthew Wilson
- Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
- Applicant Address: GB Brentford
- Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
- Current Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
- Current Assignee Address: GB Brentford
- Agency: Dechert LLP
- Agent Andrea L. C. Reid
- International Application: PCT/IB2016/000761 WO 20160519
- International Announcement: WO2016/185279 WO 20161124
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D403/14 ; C07D498/06 ; C07D498/04
Abstract:
Compounds of formula (I): wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
Public/Granted literature
- US20180297983A1 BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS Public/Granted day:2018-10-18
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