This is directed to animating transitions in a user interface as the orientation of the user interface changes. An electronic device can display a user interface in any suitable orientation, including for example in portrait and landscape modes (e.g., based on the orientation of the display). To provide a resource efficient and aesthetically pleasing transition, the electronic device can pre-render the interface in the final orientation, and define an animation by cross-fading the interface between the initial and final interfaces. In some embodiments, the electronic device can identify distinct regions of the interface, and define separate animations for each region. The separate animations can be overlaid and displayed simultaneously to provide a uniform animated transition between the initial and final interfaces.