An exemplary item return shipping system is configured to: receive a request to return an item to a retailer; provide the user with a unique identifier associated with the request; and receive an indication that the user has presented the parcel and the unique identifier at an access point. The system may then facilitate placement of a pre-printed machine-readable indicia (e.g., a barcode) on the parcel at the access point and associate it with the retailer information. The system then facilitates delivery of the parcel from the access point to a handling facility and facilitates placement of a shipping label (that includes the address of a returns processing facility that is determined using the retailer information) on the parcel at the handling facility. In various embodiments, the system then facilitates shipment of the parcel to the returns processing facility.