A flexible display panel, a manufacturing method thereof and a flexible display device, which relate to the technical field of flexible display and reduce the probability of the occurrence of cracks on an inorganic encapsulation structure when a flexible display panel is bent, so that the service life of light emitting devices in the flexible display substrate is prolonged. The flexible display panel includes a flexible display substrate and an encapsulation structure arranged on a surface of the flexible display substrate. A portion of the encapsulation structure corresponding to a non-display region is an inorganic encapsulation structure. The flexible display panel further includes an organic encapsulation layer covering the inorganic encapsulation structure. The manufacturing method of a flexible display panel manufacture the flexible display panel described in the above technical solutions. The flexible display panel provided by the present disclosure is used in a flexible display device.