Example implementations relate to cross-calibration of imagers. For example, cross-calibration of imagers can include modeling a response of each of a plurality of imagers to a color sample, modeling a response of a composite the a plurality of imagers to the color sample based on the modeled response of each of the plurality of imagers to the color sample, generating generate a cross-calibration of the modeled response of each of the plurality of imagers to the modeled response of the composite of the plurality of imagers, and generating a calibration of the modeled response of the composite of the plurality of imagers to a response of a reference imager.