An oral care dispenser system in one embodiment includes a toothbrush and removable dispenser. The dispenser includes an elongated housing with reservoir containing an oral care material, an applicator at a distal end, and an actuator at a proximal end. An elevator disposed in the housing forms a movable wall of the reservoir. The elevator is operably coupled to a drive screw via an extension member threadably engaged with the screw. Rotating the drive screw in a first direction with the actuator distally advances the elevator in the housing to dispense the oral care material. The elevator is retractable by rotating the actuator in a second direction without uncoupling elevator from the extension member.