A method and a device for determining a program performance interference model is described. The method includes: selecting programs from a determined sample program set to form multiple subsets; acquiring a value of performance interference imposed on each program in each subset and a total occupancy rate of a shared resource occupied by all the programs in each subset; dividing all the subsets into multiple analytical units; performing a regression analysis on the value of performance interference on each sample program included in each analytical unit and a total occupancy rate corresponding to a subset in which the sample program is loaded, and acquiring a target function model; acquiring a performance interference model corresponding to a target program according to the target function model. The performance interference model may be used for preventing another program whose mutual interference is relatively strong from running together with the target program.