A display driving method, a display panel and a manufacturing method thereof, and a display apparatus are provided. The display driving method comprises: driving a display area of a display panel by using at least two data driving circuits (101); driving a part of display area of the display panel by each of the data driving circuits (102); and splicing display areas driven by respective data driving circuits as an entire display area (103). In the display driving method, the display area of the display panel is driven for display by using a plurality of data driving circuits. In this way, the display area driven by each of the data driving circuits is relatively small, and then a difference value of a distance from the data driving circuit to respective columns of sub-pixels within the driven display area is relatively small, so that the resulted difference of luminance is weakened.