A computer-implemented method to monitor application program interface (API) endpoints may include sending, over a network from a computing system, a test structure to an API endpoint. In some embodiments, the test structure may be configured based on the API endpoint. The method may further include receiving a first response over the network at the computing system from the API endpoint in response to sending the test structure and resending, over the network from the computing system, the test structure to the API endpoint. The method may further include receiving a second response at the computing system from the API endpoint in response to resending the test structure and comparing, at the computing system, the first response and the second response. The method may further include determining, at the computing system, a status of the API endpoint based on the comparison of the first response and the second response.