Described herein are apparatus, systems and methods for adaptive segment size for data transmissions. A method may comprise, at a user equipment (“UE”), identifying a current size setting of a data segment (e.g., a transmission control protocol (“TCP”) maximum segment size (“MSS”)) for communication over a network, receiving current physical layer conditions, receiving historical data, and adjusting the current size setting based on at least one of the current physical layer conditions and the historical data.