Invention Grant
- Patent Title: Anti-IL-17A Antibodies
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Application No.: US15254225Application Date: 2016-09-01
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Publication No.: US10442869B2Publication Date: 2019-10-15
- Inventor: Andrey Borisovich Ulitin , Stanislav Rudolfovich Evdokimov , Valeriy Vladimirovich Soloviev , Yulia Sergeevna Chernyh , Olga Vladimirovna Goncharova , Dmitriy Valerievich Korzhavin , Tatyana Veniaminovna Chernovskaya , Timofey Aleksandrovich Nemankin , Roman Alexeevich Ivanov , Dmitriy Valentinovich Morozov , Victoria Mikhailovna Ekimova , Ekaterina Vladimirovna Sofronova , Yakov Yurevich Ustyugov
- Applicant: CLOSED JOINT STOCK COMPANY “BIOCAD”
- Applicant Address: RU Saint Petersburg
- Assignee: CLOSED JOINT STOCK COMPANY “BIOCAD”
- Current Assignee: CLOSED JOINT STOCK COMPANY “BIOCAD”
- Current Assignee Address: RU Saint Petersburg
- Agency: Anglehart et al.
- Priority: RU2014138740 20140926
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/46 ; A61K45/06 ; C07K16/24
Abstract:
The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
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