A processor may comprise a plurality of cores operating at heterogeneous frequencies communicatively coupled by a network of routers also operating at heterogeneous frequencies. A core may be prioritized for thread execution based on operating frequencies of routers on a path from the core to a memory controller. Relatively higher priority may be assigned to cores having a path comprising only routers operating at a relatively higher frequency. A combined priority for thread execution may be based on core frequency, router frequency, and the frequency of routers on a path from the core to a memory controller. A core may be selected based primarily on core operating frequency when cache misses fall below a threshold value.