Invention Grant
- Patent Title: N-(pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease
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Application No.: US15688089Application Date: 2017-08-28
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Publication No.: US10450273B2Publication Date: 2019-10-22
- Inventor: Mihai Azimioara , Bei Chen , Robert Epple , Ayako Honda , Philip Lam , Hasnain Ahmed Malik , Casey Jacob Nelson Mathison , Truc Ngoc Nguyen , Victor Ivanovich Nikulin , Sejal Patel , Dean Paul Phillips , Rodrigo A. Rodriguez , Baogen Wu , Xuefeng Zhu
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Daniel E. Raymond
- Main IPC: C07D213/76
- IPC: C07D213/76 ; C07D401/14 ; A61K31/444 ; C07D401/12 ; A61K31/4545 ; A61K31/46 ; A61K31/496 ; A61K31/4985 ; A61K31/5377 ; A61K45/06 ; C07D405/14 ; C07D487/04 ; C07D487/10 ; C07D491/107 ; C07D493/08
Abstract:
The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
Public/Granted literature
- US20180072673A1 N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease Public/Granted day:2018-03-15
Information query
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