Invention Grant
- Patent Title: Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
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Application No.: US15988806Application Date: 2018-05-24
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Publication No.: US10450301B2Publication Date: 2019-10-22
- Inventor: Brett Granger , Guoqiang Wang , Ruichao Shen , Jing He , Yong He , Xuechao Xing , Jun Ma , Jiang Long , Bin Wang , Yat Sun Or
- Applicant: ENANTA PHARMACEUTICALS, INC.
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Edgar W. Harlan; Carolyn S. Elmore, Esq.
- Main IPC: A61K31/4375
- IPC: A61K31/4375 ; A61K31/4725 ; C07D401/14 ; C07D471/04 ; C07D471/08 ; C07D417/14 ; C07D451/02 ; C07D451/06

Abstract:
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).
Public/Granted literature
- US20180362503A1 APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF Public/Granted day:2018-12-20
Information query
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