The present disclosure provides an operation instruction response control method and terminal for a human-machine interface. An operation instruction is compared with an operation instruction at the tail of an operation instruction queue while the human-machine interface is in a busy state, and stored in the operation instruction queue while the operation instruction is inequivalent to the operation instruction at the tail of the operation instruction queue; the operation instruction is stored in the operation instruction queue directly while the human-machine interface is not in the busy state. The present disclosure is capable of keeping receiving operation instructions while the human-machine interface is busy, and filtering out invalid operation instructions to avoid the backlog, which shortens the delay time of the response to the operation instructions.