Electronic design automation systems and methods for functional reactive parameterized cells (FR-PCells) are described. In one embodiment, a PCell includes a reactive parameter that is based on context information regarding other cells or elements of an overall circuit design. Processing of the FR-PCell may then depend on processing of other PCells or other elements of a circuit design. Similarly, an FR-PCell may provide context information to other FR-PCells. In some embodiments, processing of an FR-PCell to generate an instance of the FR-PCell is managed by a reaction engine that monitors updates to context information or other PCells to automatically adjust instances of the FR-PCells.