Embodiments of the present disclosure provide a resource configuration method and a resource configuration network device. The method includes: obtaining subframe information of each of multiple cells, where the subframe information of each of the multiple cells includes subframe configuration information and flexible subframe resource requirement information of each cell; and determining a flexible subframe resource configuration of each cell according to the subframe information of each of the multiple cells, where the flexible subframe resource configuration of each cell includes that each cell uses one or more of N flexible subframes to perform data transmission. A flexible subframe resource requirement of each of multiple neighboring cells is obtained, and flexible subframe resource configurations of the cells are coordinated in a distributed manner according to a subframe configuration and the flexible subframe resource requirement of each cell, thus, cross-subframe interference that may exist between flexible subframes can be reduced.