Invention Grant
- Patent Title: Optofluidic sorter
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Application No.: US15503369Application Date: 2015-08-19
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Publication No.: US10466156B2Publication Date: 2019-11-05
- Inventor: Daniel Y. Chu , Paul J. Patt , Roger Tong
- Applicant: BIO-RAD LABORATORIES, INC.
- Applicant Address: US CA Hercules
- Assignee: Bio-Rad Laboratories, Inc.
- Current Assignee: Bio-Rad Laboratories, Inc.
- Current Assignee Address: US CA Hercules
- Agency: Kilpatrick Townsend and Stockton LLP
- International Application: PCT/US2015/045924 WO 20150819
- International Announcement: WO2016/028907 WO 20160225
- Main IPC: G01N15/14
- IPC: G01N15/14 ; B01L3/00 ; C12Q1/04 ; G01N15/10

Abstract:
A method is provided for transporting a plurality of cells through a flow chamber, wherein the cells are initially immobilized on an internal surface of the flow chamber. The method comprises: selectively releasing the cells from the internal surface of the flow chamber; and flowing liquid through the flow chamber such that the released cells travel with the liquid, thereby transporting the cells through the flow chamber. Cells can be immobilized on or selectively released from the internal surface by applying or removing a trapping potential. The trapping potential can arise from an electric field gradient or an optical field gradient. Alternatively, cells can be selectively released from the surface using photocatalysis. Selective release allows cells to be individually observed or analyzed downstream, and can be based on a signal detected from one or more cells immobilized on the surface.
Public/Granted literature
- US20170241888A1 OPTOFLUIDIC SORTER Public/Granted day:2017-08-24
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