An example method of migrating a virtualized computing instance between source and destination virtualized computing systems includes executing a first migration workflow in the source virtualized computing system, where a host computer executing the virtualized computing instance is a source host in the first migration workflow and a first mobility agent simulates a destination host in the first migration workflow. The method further includes executing a second migration workflow in the destination virtualized computing system, where a second mobility agent in the destination virtualized computing system simulates a source host in the second migration workflow and a host computer in the destination virtualized computing system is a destination host in the second migration workflow. The method further includes transferring, during execution of the first and second migration workflows, migration data including the virtualized computing instance between the first mobility agent and the second mobility agent over a network.