![Pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl) butan-1-one for inhibiting serotonin reuptake transporter activity](/docs/US/2019-11-12/US10472359B2/abs.jpg.600x600.jpg)
- Patent Title: Pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl) butan-1-one for inhibiting serotonin reuptake transporter activity
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Application No.: US16056143Application Date: 2018-08-06
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Publication No.: US10472359B2Publication Date: 2019-11-12
- Inventor: Peng Li , Qiang Zhang , Robert Davis , Lawrence P. Wennogle
- Applicant: INTRA-CELLULAR THERAPIES, INC.
- Applicant Address: US NY New York
- Assignee: INTRA-CELLULAR THERAPIES, INC.
- Current Assignee: INTRA-CELLULAR THERAPIES, INC.
- Current Assignee Address: US NY New York
- Agency: Hoxie & Associates LLC
- Main IPC: C07D471/22
- IPC: C07D471/22 ; C07D471/16 ; C07D471/14 ; A61K9/48 ; A61K31/4985 ; A61K47/34 ; A61K47/38 ; A61K9/50
![Pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl) butan-1-one for inhibiting serotonin reuptake transporter activity](/abs-image/US/2019/11/12/US10472359B2/abs.jpg.150x150.jpg)
Abstract:
The invention relates to pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one in toluenesulfonic acid addition salt form: and methods of use in the treatment of diseases involving the 5-HT2A receptor pathway, the serotonin transporter (SERT) pathway and/or the dopamine D2 receptor pathway signaling systems.
Public/Granted literature
- US20190071445A1 ORGANIC COMPOUNDS Public/Granted day:2019-03-07
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