The disclosure relates to smart security inspection systems and methods. One illustrative method may comprise distributing, by the system, a security inspection tray to a person to be inspected through an unpacking station and associating/binding information regarding the person to be inspected to a baggage identifier, and identifying the baggage identifier, obtaining the information of the person to be inspected according to the baggage identifier, obtaining pre-stored risk information according to the information of the person to be inspected, performing differentiated security inspections on the person to be inspected and/or baggage according to the risk information, and associating/binding the obtained data to the information of the person to be inspected. Further implementations relate to features such as processing identity information, controlling flow in the baggage handling area(s), imaging baggage, packing the baggage, and finishing the security inspection.