A single-ended signal transmission system recovers a noise signal associated with a data input signal and uses the recovered noise signal to compensate for noise on the data input signal. The noise signal may be recovered from a noise reference signal line, or clock signal line, or a data signal line associated with a DC-balanced data input signal. The recovered noise signal may be represented as an analog signal or a digital signal. The recovered noise signal may be processed to compensate for DC offset and nonlinearities associated with one or more different input buffers. In one embodiment, the recovered noise signal includes frequency content substantially below a fundamental frequency for data transmission through the data input signal.