The present disclosure is directed towards systems and methods for detecting anomalous network traffic. Network traffic corresponding to an application executed by a server can be received. Application characteristics of the application can be identified to select an anomaly detection profile. The anomaly detection profile can be selected based on the identified application characteristics. The anomaly detection profile can include a set of detection features for the anomaly and one or more predetermined threshold values of the detection features. One or more feature values of the set of one or more detection features can be determined. An anomaly in the network traffic can be detected responsive to comparing the feature values and the predetermined threshold values of the detection features.